Diabetic

Diabetic Spontaneous Mutant Mouse Model
  • Cryopreserved
  • Mouse
  • Various
  • Available for direct purchase by CRO
Model No.NomenclatureGenotype
DBBKS.Cg-m+/+Leprdb/BomTacsp/sp
DB-MBKS.Cg-m+/+Leprdb/BomTacsp/sp
DB-FBKS.Cg-m+/+Leprdb/BomTacsp/wt
DB-MBKS.Cg-m+/+Leprdb/BomTacsp/wt
DB-FBKS.Cg-m+/+Leprdb/BomTacwt/wt
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Overview

Nomenclature: BKS.Cg-m+/+Leprdb/BomTac

  • A suitable model for the study of diabetic neuropathology and nephropathy
  • Also used in the study of the pathogenesis and prevention of Type II Non-Insulin Dependent Diabetes Mellitus (NIDDM)
  • Experiences a hyperinsulinemic phase (Phase 1) followed by a hypoinsulinemic phase (Phase 2) at 2-3 months of age
  • Genotype shown in the table above refers to the Lepr gene
  • Due to possible crossover of the misty (m) and Leprdb genes, a low percentage of DB-M could be heterozygous for the misty (m) gene
  • Only homozygotes (black) are diabetic and obese, heterozygotes (black) and wild types (misty) are non-diabetic and lean *Pricing is for ungenotyped lean or obese animals. Customers wanting genotyped animals must allow for an extra 2 week leadtime.

Origin

The Diabetic Spontaneous mutant model was developed by Hummel et al in 1959 by discovering a Lepr db mutation on a C57BLKS background. M&B A/S (now Taconic Europe) received stock from CERJ France in 1991. The mice were derived by embryo transfer in 2005 at Taconic US and are maintained by incrossing brother x sister mice.

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