| Model No. | Nomenclature | Genotype |
|---|---|---|
| GK | GK/MolTac |
Goto-Kakizaki
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Overview
Nomenclature: GK/MolTac
- A non-obese model of Non-Insulin Dependent Diabetes Mellitus (NIDDM), type II diabetes.
- It exhibits similar metabolic, hormonal, and vascular disorders to the human diabetes disease.
- Males develop type II diabetes at approximately 14 - 16 weeks of age.
- Characteristics include fasting hyperglycemia, impaired secretion of insulin in response to glucose both in vivo and in isolated pancreatic cells, hepatic and peripheral insulin resistance and polyuria
- Late complications such as retinopathy, microangiopathy, neuropathy, and nephropathy have been described in literature
- Phenotypes, particularly blood glucose, are diet dependent and we recommend feeding NIH31-M.
- The GK colony was derived from inbred stock and was bred randomly in a closed colony.
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- Diabetes
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Transit, Housing & Welfare
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Data
Average litter size: 6
- Sexual Maturity: females at approximately 8 - 10 weeks of age males at approximately 10 - 12 weeks of age
- Pregnancy: approximately 21 - 23 days
- Weaning: approximately 28 days of age
- Phenotypes, particularly blood glucose, are diet dependent and we recommend feeding NIH31-M.
n= 100 per sex at MPF health standard from US production colonies. Data collected 2012-14.
High and Low represent mean +/- 2 standard deviations.
Based on sample size the charts above represents ~90% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves. Growth charts are provided only as a guide.
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