Academic Research - Pool of available GEMs increases by 75 models

Kenneth Platt, PhD
Friday, December 11th, 2015
Taconic Biosciences has recently added an additional 75 mouse models to the GEM Collection Repository. The GEM Collection's nearly 300 lines provide academic and nonprofit researchers worldwide with unparalleled access to a wide range of genetically engineered mouse models.

These mouse models are relevant to several disease areas, such as cardiovascular, diabetes/ endocrinology, neuroscience, oncology, respiratory, and immunology. The GEM Collection repository offers nonprofit researchers immediate access to expertly designed, highly valuable research tools that rapidly accelerate functional genetic research. The collection provides resources to study the effect of both loss (constitutive and conditional) and gain of function mutations in the context of the whole animal.

The lines are maintained as frozen germplasm (sperm and/or embryos) allowing academic researchers on demand access with rapid recovery times. Eliminating the time associated with the design and development of these mouse models provides a tremendous competitive advantage.

  • Accelerated Time Lines: Live mice can be obtained in about 17 weeks. Lines are generally recovered from frozen sperm using state of the art embryological services.
  • Genetic Integrity: Most lines are congenic with the C57BL/6NTac inbred background. No time-consuming backcrossing is necessary.
  • Significantly Reduced Investment: Low cost access to complex models. There are no license fees giving nonprofits cost-effective access to the collection.

New Model Details

Taconic CatalogGene SymbolAllele TypeGene FamilyGene Accession
7917AclycKOSynthaseNM_134037
10412AclyKOSynthaseNM_134037
7975AgrpKONeuropeptideNM_007427
8265Atp6ap2cKOATPaseNM_027439
7932Bace1KOProteaseNM_001145947
8037Cd300lbTgReceptorNM_199221
8038Cd300lbTgReceptorNM_199221
8039Cd300lbTgReceptorNM_199221
8041Cd300lbTgReceptorNM_199221
8040Cd300lgTgReceptorNM_001160713
8087ChiaKOChitinaseNM_023186
11163Clec5a (Mdl1)cKOLectinNM_001038604
12015Cyp8b1cKOHydrolaseNM_010012
11784Cyp8b1KOHydrolaseNM_010012
10053Dpp4cKOPeptidaseNM_010074
10397Enpp1hTgPhosphodiesteraseNM_006208
10896Fabp4KOEnzyme activatorNM_024406
11165Fabp4&5dKOEnzyme activatorNM_010634
9569Fbxo32cKOInhibitorNM_026346
10058Fbxo40cKOLigaseNM_001037321
10181Fgf21TgGrowth factorNM_020013
11364Fgfr1cKOReceptorNM_010206
11334Fgfr3cKOReceptorNM_001205270
9704GcgrKOReceptorNM_008101
10888Gpr120KOG-protein coupled receptorNM_181748
11021Grik1cKOReceptorNM_146072
10889Hrh3KOReceptorNM_133849
TTM 612Il1bKOCytokineNM_008361
12685Irf5KORegulatory factorNM_001252382
12646Irf5cKORegulatory factorNM_001252382
8052Jak2cKOKinaseNM_001048177
12079Kcnj1KOIon channelNM_019659
11481Kcnj1cKOIon channelNM_019659
8734Kcnk3cKOIon channelNM_010608
8799Keap1cKOInhibitorNM_001110305
11432KlbKOReceptorNM_031180
11155Lair1KOReceptorNM_001113474
7904Lrrtm3KOLeucine rich repeatNM_178678
12849Magt1KOTransporterNM_001190409
12847Magt1cKOTransporterNM_001190409
8977MaptcKOMicrotubuleNM_010838
10771MaptKOMicrotubuleNM_010838
9743Mir34aKOmicroRNANR_029751
9512Mir34acTTGmicroRNANR_029751
9746Mir34bcKOmicroRNANR_029655
9717Mir34bccKOmicroRNANR_029655
9745Mir122acKOmicroRNANR_029600
9568Mir122acTTGmicroRNANR_029600
9983Mir449a_b_cKOmicroRNANR_029961
15453Mmp3KOPeptidaseNM_010809
13143Nfe2l2KONuclear factorNM_010902
13107Nfe2l2cKONuclear factorNM_010902
12935Nlrp3KOATPaseNM_145827
12809Nlrp3cKOATPaseNM_145827
12889Nod2cKOCaspaseNM_145857
12888Nod2KOCaspaseNM_145857
12910Nod2cTTGCaspaseNM_145857
13233Npr3KOReceptorNM_008728
13105Npr3cKOReceptorNM_008728
10898Pcsk9cKOProteaseNM_153565
12728PilraKOReceptorNM_153510
8069Pkmyt1cKOKinaseNM_023058
10595Prkag3KOKinaseNM_153744
13103Prkg2cKOKinaseNM_008926
7915Prmt2KOTransferaseNM_001077638
12834Rock1cKOKinaseNM_009071
12905Rock2cKOKinaseNM_009072
9508Rps6ka1KOKinaseNM_009097
9329Slc22a6-a8dKOSolute carrierNM_008766, NM_001164634
11785SykbcKOKinaseNM_001198977
12684Tyk2KOKinaseNM_001205312
12647Tyk2cKOKinaseNM_001205312
8726Vnn1KOHydrolaseNM_011704
Coupled with Taconic's core capability of custom breeding, the GEM Collection can provide research labs with the animals they need to rapidly produce study data, without the additional work and cost of animal colony production and maintenance.

Advance your research — search the entire GEM Collection today.

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