About the webinar:
Animal models for COVID-19 have been indispensable to the rapid development of vaccines and therapeutics for this disease, and they continue to be used for these purposes and to study disease pathogenesis of SARS-CoV-2 infection. Mice are a common preclinical model, but the species tropism of SARS-CoV-2 means that standard wild type inbred and outbred mice are resistant to infection due to differences in the ACE2 protein used by the virus to gain entry into cells. Mice that express human ACE2 are susceptible to infection with SARS-CoV-2 and serve as a useful preclinical model for COVID-19 research.
In this webinar, Drs. Grizotte-Lake and Kar will introduce the hACE2 AC70 mouse model and review data from experiments directed at developing a SARS-CoV-2 infection model, including several viral variants of interest. Learn more about study design for COVID-19 experiments, including endpoint selection and analysis, and understand how the hACE2 AC70 mouse model can be applied to studies of COVID-19 prevention and treatment.
Watch this webinar to:
- Understand the SARS-CoV-2 infection timeline and clinical disease manifestation in the hACE2 AC70 Mouse, for several SARS-CoV-2 variants
- Uncover the value of using wild type viral isolates rather than mouse-adapted viruses for COVID-19 studies
- Learn about relevant endpoints for SARS-CoV-2 studies, including survival, viral shedding, tissue viral load, cytokine analysis, phenotypic analysis of immune cells and more
- Discover how the hACE2 AC70 Mouse can be used for efficacy studies related to COVID-19 prevention and treatment
