| Model No. | Nomenclature | Genotype |
|---|---|---|
| MDR1A-F | FVB.129P2-Abcb1atm1Bor N7 | ko/ko |
| MDR1A-M | FVB.129P2-Abcb1atm1Bor N7 | ko/ko |
Mdr1a
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Overview
Nomenclature: FVB.129P2-Abcb1atm1Bor N7
- Carries a disruption of multi-drug resistance genes Abcb1a (ATP-binding cassette, sub-family B (MDR/TAP), member 1A, a.k.a. Mdr1a) encoding p-glycoprotein 3
- Mdr1a protein is expressed actively in the intestine and at the blood-brain and blood-testis barriers
- p-glycoprotein 3 actively extrudes a wide range of drugs from cells and can confer multi-drug resistance to tumor cells
- Lack the protective function of p-glycoprotein 3 and exhibits a functional deficiency in the blood-brain barrier
- Useful in neurotoxicology, drug transport, chemotherapy, multi-drug resistance and oral bioavailability research
- Susceptible to developing a severe, spontaneous intestinal inflammation phenotypically similiar to human inflammatory bowel disease (IBD)
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Origin
The Mdr1a mouse was developed in the laboratory of Alfred Schinkel of the Netherlands Cancer Institute. The model was created by targeting the Abcb1a gene in E14 ES cells. Resultant chimeras were backcrossed to FVB for seven (N7) generations. Taconic received stock in 1994 and derived the line by Caesarean transfer. The colony is maintained by incrossing homozygous mice.
Genetics
Guides & Publications
Initial Publication:
Schinkel AH, Smit JJM, van Tellingen O, Beijnen JH, Wagenaar E, van Deetmer L, Mol CAAM, van der Valk MA, Robanus-Maandag BC, te Tiele HPJ, Berns AJM, Borst P. (1994) Disruption of the Mouse mdr1a P-Glycoprotein Gene Leads to a Deficiency in the Blood Brain Barrier and to Increased Sensitivity to Drugs. Cell, 77:491-502.
Applications & Therapeutic Areas
- ADMET
- Inflammation
- Inflammatory Bowel Disease
- Microbiome
- Neuroscience
- Safety Assessment
- Autoimmune Disease
- Immunology
Transit, Housing & Welfare
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Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
- Services
Data
Baseline phenotypic data (blood counts and chemistry, organ weights, urinalysis)
Spontaneous Colitis in MDR1A Mice
Representative data for spontaneous colitis in MDR1A mice provided by Bolder BioPATH. Download the full data package, including protocol information, body weight change, endoscope scores and representative endoscopy images, disease activity scores, colon weights, histopathology scores and efficacy of anti-IL-12 treatment.
- Licensing
- Pricing - USD
- Pricing - EUR
- Pricing - USD Nonprofit
- Pricing - EUR Nonprofit
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Mdr1a
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
- Title to these Models and biological materials derived from them remains with Taconic.
- The Models will be used for research purposes only.
- The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
- The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
- Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Pricing - USD
Murine Pathogen Free (MPF) Health Standard
MDR1A Female
MDR1A-F Genotype ko/ko
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | $417.00 |
Specialized Inventory
| MDR1A-RF Genotype ko/ko | Quantity 1 - 199 |
| Retired Female Breeder | $417.00 |
MDR1A Male
MDR1A-M Genotype ko/ko
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | $417.00 |
Specialized Inventory
| MDR1A-RM Genotype ko/ko | Quantity 1 - 199 |
| Retired Male Breeder | $417.00 |
Pricing - EUR
Murine Pathogen Free (MPF) Health Standard
MDR1A Female
MDR1A-F Genotype ko/ko
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | €381,00 |
Specialized Inventory
| MDR1A-RF Genotype ko/ko | Quantity 1 - 199 |
| Retired Female Breeder | €381,00 |
MDR1A Male
MDR1A-M Genotype ko/ko
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | €381,00 |
Specialized Inventory
| MDR1A-RM Genotype ko/ko | Quantity 1 - 199 |
| Retired Male Breeder | €381,00 |
Pricing - USD Nonprofit
Murine Pathogen Free (MPF) Health Standard
MDR1A Female
MDR1A-F Genotype ko/ko
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | $292.00 |
Specialized Inventory
| MDR1A-RF Genotype ko/ko | Quantity 1 - 199 |
| Retired Female Breeder | $292.00 |
MDR1A Male
MDR1A-M Genotype ko/ko
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | $292.00 |
Specialized Inventory
| MDR1A-RM Genotype ko/ko | Quantity 1 - 199 |
| Retired Male Breeder | $292.00 |
Pricing - EUR Nonprofit
Murine Pathogen Free (MPF) Health Standard
MDR1A Female
MDR1A-F Genotype ko/ko
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | €267,00 |
Specialized Inventory
| MDR1A-RF Genotype ko/ko | Quantity 1 - 199 |
| Retired Female Breeder | €267,00 |
MDR1A Male
MDR1A-M Genotype ko/ko
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | €267,00 |
Specialized Inventory
| MDR1A-RM Genotype ko/ko | Quantity 1 - 199 |
| Retired Male Breeder | €267,00 |
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