| Model No. | Nomenclature | Genotype |
|---|---|---|
| 1006-F | B6.Cg-Tg(TNF)#Xen | tg/wt |
| 1006-M | B6.Cg-Tg(TNF)#Xen | tg/wt |
| 1006-F | B6.Cg-Tg(TNF)#Xen | wt/wt |
| 1006-M | B6.Cg-Tg(TNF)#Xen | wt/wt |
TNF-α
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Overview
Nomenclature: B6.Cg-Tg(TNF)#Xen
- Express the human tumor necrosis factor α (TNF-α) transgene, a cytokine implicated in the pathogenesis of human rheumatoid arthritis
- Exhibits severe chronic arthritis of the forepaws and hind paws, as shown by gross observation and histological analysis by approximately 20 weeks of age
- A useful model for studying inflammatory arthritis which does not require experimental manipulation
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Origin
Genetics
Guides & Publications
Initial Publication: Hayward MD, Jones BK, Saparov A, Hain HS, Trillat A-C, Bunzel MM, Corona A, Li-Wang B, Strenkowski B, Giordano C, Shen H, Arcamone E, Weidlick J, Vilensky M, Tugusheva M, Felkner RH, Campbell W, Rao Y, Grass DS, Buiakova O. (2007) An extensive phenotypic characterization of the hTNFα transgenic mice. BMC Physiology, 7:13.
Applications & Therapeutic Areas
- Autoimmune Disease
- Genetically Humanized
- Immunology
- Inflammation
Transit, Housing & Welfare
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Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
Data
Phenotypic Disease Observations:
Onset of Arthritis-Clinical Signs in Hindlimbs
TNF-α Transgenic Mice and non-transgenic age-matched controls comparing signs of disease progression.
TNF-α Transgenic Mice and non-transgenic age-matched controls comparing signs of disease progression.
5 weeks: normal appearance; no detectable symptoms
9 weeks: mild disease; minor loss of flexibility in digits; minimal joint swelling and distortion
14 weeks: moderate disease; moderate distortion and twisting of hindpaw and moderate swelling of joints
20 weeks: severe disease; distortion and swelling of joints
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TNF-α
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
- Title to these Models and biological materials derived from them remains with Taconic.
- The Models will be used for research purposes only.
- The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
- The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
- Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Pricing - USD
Murine Pathogen Free (MPF) Health Standard
1006 Female
1006-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $583.00 |
1006-F Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $380.00 |
1006 Male
1006-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $583.00 |
1006-M Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $380.00 |
Pricing - EUR
Murine Pathogen Free (MPF) Health Standard
1006 Female
1006-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €506,00 |
1006-F Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €324,00 |
1006 Male
1006-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €506,00 |
1006-M Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €324,00 |
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