TNF-α

Model No.	Nomenclature	Genotype
1006-F	B6.Cg-Tg(TNF)#Xen	tg/wt
1006-M	B6.Cg-Tg(TNF)#Xen	tg/wt
1006-F	B6.Cg-Tg(TNF)#Xen	wt/wt
1006-M	B6.Cg-Tg(TNF)#Xen	wt/wt

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Description
Data
Price & Licensing
Health Report

Overview

Nomenclature: B6.Cg-Tg(TNF)#Xen

Express the human tumor necrosis factor α (TNF-α) transgene, a cytokine implicated in the pathogenesis of human rheumatoid arthritis
Exhibits severe chronic arthritis of the forepaws and hind paws, as shown by gross observation and histological analysis by approximately 20 weeks of age
A useful model for studying inflammatory arthritis which does not require experimental manipulation

Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Origin

The TNF-α mouse was developed by Xenogen Biosciences, now Taconic. The model was created by microinjecting the human TNF-α gene. Taconic received stock in April 1996 at the second backcross from the C57BL/6 x SJL founder line. The mice were maintained by backcrossing hemizygous TNF-α mice to C57BL/6NTac inbred mice.

Guides & Publications

Initial Publication: Hayward MD, Jones BK, Saparov A, Hain HS, Trillat A-C, Bunzel MM, Corona A, Li-Wang B, Strenkowski B, Giordano C, Shen H, Arcamone E, Weidlick J, Vilensky M, Tugusheva M, Felkner RH, Campbell W, Rao Y, Grass DS, Buiakova O. (2007) An extensive phenotypic characterization of the hTNFα transgenic mice. BMC Physiology, 7:13.

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Transit, Housing & Welfare

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Packing Practices

Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.

Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.

Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.

Data

Phenotypic Clinical Chemistries of TNF-α

Total and Differential Cell Counts for TNF-α using FACS Analysis

Pathology Report

Phenotypic Disease Observations:

Onset of Arthritis-Clinical Signs in Hindlimbs
TNF-α Transgenic Mice and non-transgenic age-matched controls comparing signs of disease progression.

5 weeks: normal appearance; no detectable symptoms
TNF-α at 5 weeks

9 weeks: mild disease; minor loss of flexibility in digits; minimal joint swelling and distortion
TNF-α at 9 weeks

14 weeks: moderate disease; moderate distortion and twisting of hindpaw and moderate swelling of joints
TNF-α at 14 weeks

20 weeks: severe disease; distortion and swelling of joints
TNF-α at 20 weeks

TNF-α

Conditions of Use for Taconic Transgenic Models™

Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:

Title to these Models and biological materials derived from them remains with Taconic.
The Models will be used for research purposes only.
The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.

Pricing - USD

Health Standard Available

Murine Pathogen Free (MPF) Health Standard

1006 Female

1006-F Genotype tg/wt

Available now

Age in Weeks	Quantity 1 - 999
4 to 10	$ 425.00

1006-F Genotype wt/wt

Cohorts are reserved upon order placement and will take 4-8 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.

Age in Weeks	Quantity 1 - 999
4 to 10	$ 425.00

1006 Male

1006-M Genotype tg/wt

Cohorts are reserved upon order placement and will take 4-8 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.

Age in Weeks	Quantity 1 - 999
4 to 10	$ 425.00

1006-M Genotype wt/wt

Cohorts are reserved upon order placement and will take 4-8 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.

Age in Weeks	Quantity 1 - 999
4 to 10	$ 425.00

Pricing - EUR

Health Standard Available

Murine Pathogen Free (MPF) Health Standard

1006 Female

1006-F Genotype tg/wt

Available now

Age in Weeks	Quantity 1 - 999
4 to 10	387,00 €

1006-F Genotype wt/wt

Cohorts are reserved upon order placement and will take 4-8 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.

Age in Weeks	Quantity 1 - 999
4 to 10	387,00 €

1006 Male

1006-M Genotype tg/wt

Cohorts are reserved upon order placement and will take 4-8 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.

Age in Weeks	Quantity 1 - 999
4 to 10	387,00 €

1006-M Genotype wt/wt

Cohorts are reserved upon order placement and will take 4-8 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.

Age in Weeks	Quantity 1 - 999
4 to 10	387,00 €

Pricing - USD Nonprofit

Health Standard Available

Murine Pathogen Free (MPF) Health Standard

1006 Female

1006-F Genotype tg/wt

Available now

Age in Weeks	Quantity 1 - 999
4 to 10	$ 425.00

1006-F Genotype wt/wt

Cohorts are reserved upon order placement and will take 4-8 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.

Age in Weeks	Quantity 1 - 999
4 to 10	$ 425.00

1006 Male

1006-M Genotype tg/wt

Cohorts are reserved upon order placement and will take 4-8 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.

Age in Weeks	Quantity 1 - 999
4 to 10	$ 425.00

1006-M Genotype wt/wt

Cohorts are reserved upon order placement and will take 4-8 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.

Age in Weeks	Quantity 1 - 999
4 to 10	$ 425.00

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TNF-α

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