| Model No. | Nomenclature | Genotype |
|---|---|---|
| 9177 | B6-Cyp2ctm1104Arte | Inquire for genotype |
Cyp2c Knockout Mouse
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Overview
Nomenclature: B6-Cyp2ctm1104Arte
- This model carries a deletion of fourteen full-length mouse Cyp2c genes
- Contains a cre-mediated deletion of the following genes in the Cyp2c cluster: Cyp2c55, 2c65, 2c66, 2c29, 2c38, 2c39, 2c67, 2c68, 2c40, 2c69, 2c37, 2c54, 2c50, 2c70.
- Mouse Cyp2c44, which is physically located outside of the Cyp2c Cluster has not been deleted.
- In humans, CYP2C enzymes metabolize up to 30% of marketed drugs
- Useful in dissecting the contribution of the Cyp2c family to total bioavailability of a drug
Origin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication: Scheer N, Kapelyukh Y, Chatham L, Rode A, Buechel S, Wolf CR. Generation and Characterization of Novel Cytochrome P450 Cyp2c Gene Cluster Knockout and CYP2C9 Humanized Mouse Lines. Mol Pharmacol. 2012 Aug 23.
Applications & Therapeutic Areas
- ADMET
Transit, Housing & Welfare
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Diet
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- Pricing - USD
- Pricing - EUR
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Cyp2c Knockout Mouse
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
9177
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $23,100.00 | $17,325.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
9177
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €15.855,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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