| Model No. | Nomenclature | Genotype |
|---|---|---|
| ABBN12 | B6.129-H2-Ab1tm1Gru N12 | Inquire for genotype |
Abb (H2-Ab1) - Model ABBN12
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Overview
Nomenclature: B6.129-H2-Ab1tm1Gru N12
- Contains a disruption of the H2-Ab1 gene
- Expresses no A or E MHC class II molecules and therefore lacks most CD4+ T cells
- Useful in transplantation, gene therapy and immunological disease research
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Origin
The Abb mouse was developed in the laboratory of Michael J. Grusby et al. of the Harvard School of Public Health. The model was created by targeting the H2-Ab1 gene in ES-D3 cells and injecting the targeted ES cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to C57BL/6 for 4 generations (N4). Taconic received stock from Tufts University in December 1991, and the mice were backcrossed eight additional generations (N12) to C57BL/6NTac. The mice were derived by embryo transfer and intercrossed to homozygosity.
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication:
Grusby MJ, Johnson RS, Papaioannou VE, Glimcher LH. (1991) Depletion of CD4+ T-Cells in Major Histocompatibility Complex Class II - Deficient Mice. Science, 253(5026):1417-1420.
Applications & Therapeutic Areas
- Autoimmune Disease
- Immunology
- Infectious Disease
- Inflammation
- Microbiome
- Oncology & Immuno-Oncology
- Vaccine Research
Transit, Housing & Welfare
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Diet
- Services
- Licensing
- Pricing - USD
- Select my Health Standard
- Get Custom Pricing Guide
Abb (H2-Ab1) - Model ABBN12
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
ABBN12
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $21,000.00 | $13,000.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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