| Model No. | Nomenclature | Genotype |
|---|---|---|
| 6622 | FVB.129P2-Slc22a1tm1Ahs Slc22a2tm1Ahs N7 | Inquire for genotype |
Oct1/2
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Overview
Nomenclature: FVB.129P2-Slc22a1tm1Ahs Slc22a2tm1Ahs N7
- This double targeted mutation strain carries a disruption of organic cation transporter genes Slc22a1 and Slc22a2
- Useful for studies of drug transport in the liver, intestine and kidneys
- OCT1 and OCT2 determine renal secretion of small organic cations
Origin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication:
- Jonker JW, Wagenaar E, Mol CA, Buitelaar M, Koepsell H, Smit JW, Schinkel AH. (2001) Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene. Mol Cell Biol 21(16): 5471-5477.
- Jonker JW, Wagenaar E, Van Eijl S, Schinkel AH. (2003) Deficiency in the organic cation transporters 1 and 2 (Oct1/2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations. Mol Cell Biol 23(21):7902-7908.
Applications & Therapeutic Areas
- ADMET
Transit, Housing & Welfare
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Diet
- Services
- Licensing
- Pricing - USD
- Pricing - EUR
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Oct1/2
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
6622
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $21,000.00 | $13,000.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
6622
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €13.000,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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