| Model No. | Nomenclature | Genotype |
|---|---|---|
| 1177 | B6.129S6-Rag2tm1FwaPrf1tm1Clrk N12 | Inquire for genotype |
Pfp/Rag2
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- Description
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- Overview
- Genetics
- Guides & Publications
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Overview
Nomenclature: B6.129S6-Rag2tm1FwaPrf1tm1Clrk N12
- This double targeted mutation contains a disruption of both Rag2 and Pfp genes
- Exhibits a severe depletion of NK cell function through the disruption of the Pfp gene and lacks mature T or B lymphocytes through disruption of the Rag2 gene
- Used to study overall regulation of the immune system or specific areas such as NK or CTL activity, immune suppression and transplantation
- Carries the H2b haplotype
Origin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication: Shinkai, Y, Rathbun, G, Lam, KP, Oltz, EM, Stewart, V, Mendelsohn, M, Charron, J, Datta, M, Young, F, Stall, AM, and Alt, FW. (1992) RAG-2-Deficient Mice Lack Mature Lymphocytes Owing to Inability to Initiate V(D)J Rearrangement, Cell, 68: 855-867.
Walsh CM, Matloubian M, Liu C, Ueda R, Kurahara CG, Christensen JL, Huang MTF, Young JD, Ahmed R, and Clark WR. (1994) Immune function in mice lacking the perforin gene. Proc Natl Acad Sci USA, 91(23): 10854-10858.
Applications & Therapeutic Areas
- Immunology
- Oncology & Immuno-Oncology
- Inflammation
Transit, Housing & Welfare
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Diet
- Licensing
- Pricing - USD
- Pricing - EUR
- Select my Health Standard
- Get Custom Pricing Guide
Pfp/Rag2
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
1177
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $21,000.00 | $13,000.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
1177
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €13.000,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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