| Model No. | Nomenclature | Genotype |
|---|---|---|
| CB17SC-F | C.B-Igh-1b/IcrTac-Prkdcscid | sp/sp |
| CB17SC-M | C.B-Igh-1b/IcrTac-Prkdcscid | sp/sp |
C.B-17 scid
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Overview
Nomenclature: C.B-Igh-1b/IcrTac-Prkdcscid
- This is the original congenic background strain on which Dr. Mel Bosma discovered the spontaneous scid mutation.
- Mice homozygous for the Prkdcscid mutation lack both T and B cells due to a defect in V(D)J recombination. Therefore, they easily accept foreign tissue transplants, including human tumors, making them effective models for testing new cancer treatments and as hosts for human immune system tissues (i.e., SCID-hu).
- The C.B-17 scid mice exhibit extremely low levels of Ig in ~20% of the mice at 12 weeks of age. The incidence of Ig will increase as the mice age. Despite this "leakiness" C.B-17 scids do not mount an antibody response to challenge by immunogenic material.
- Strain is similar to BALB/c except it carries the Igh-1b allele from the C57BL/Ka strain.
- Taconic has identified cardiac calcinosis in the CB17SC with an incidence of up to 50% in males at 7 weeks. Cardiac calcinosis is an incidental finding which does not cause clinical illness. Certain inbred strains such as BALB/c are predisposed to developing cardiac calcinosis.
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Genetics
Guides & Publications
Applications & Therapeutic Areas
- Immunology
- Inflammatory Bowel Disease
- Oncology & Immuno-Oncology
- Inflammation
Transit, Housing & Welfare
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Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
Data
Average litter size: 6
Hematology reference data provided courtesy of ArcticLAS.
For some applications, weight may be critical. For orders where weight is critical, please place orders by weight, not by age. Taconic can accept orders by weight for this model. For orders sourced from US or Denmark a production minimum 3 gram span is accepted. All weights are weights at time of packing. Mice and rats can lose weight in transit. Orders for specific weight spans will be assessed a nominal fee. More detail on weight order policies is available.
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Licensing
Terms of Sale and Use for C.B-17 scid
These models are sold subject to Taconic's Terms and Conditions for Taconic's Models, Products and Services
Pricing - USD
Opportunist Free (OF) Health Standard
CB17SC Female
CB17SC-F Genotype sp/sp
| Age in Weeks | Quantity 1 - 99 | Quantity 100 - 999 |
| 3 to 4 | $112.00 | $104.00 |
| 5 to 6 | $118.00 | $112.00 |
| 7 to 9 | $125.00 | $118.00 |
Specialized Inventory
| CB17SC-FL | Quantity 1 - 199 |
| Female With Litter | $743.00 |
Specialized Inventory
| CB17SC-RF Genotype sp/sp | Quantity 1 - 199 |
| Retired Female Breeder | $118.00 |
Specialized Inventory
| CB17SC-UP | Quantity 1 - 199 |
| Untimed Pregnant Female | $611.00 |
*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.
CB17SC Male
CB17SC-M Genotype sp/sp
| Age in Weeks | Quantity 1 - 99 | Quantity 100 - 999 |
| 3 to 4 | $112.00 | $104.00 |
| 5 to 6 | $118.00 | $112.00 |
| 7 to 9 | $125.00 | $118.00 |
Specialized Inventory
| CB17SC-RM Genotype sp/sp | Quantity 1 - 199 |
| Retired Male Breeder | $118.00 |
Pricing - EUR
Opportunist Free (OF) Health Standard
CB17SC Female
CB17SC-F Genotype sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 4 | €105,00 |
| 5 to 6 | €124,00 |
| 7 to 9 | €128,00 |
Specialized Inventory
| CB17SC-FL | Quantity 1 - 199 |
| Female With Litter | €571,00 |
CB17SC Male
CB17SC-M Genotype sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 4 | €105,00 |
| 5 to 6 | €124,00 |
| 7 to 9 | €128,00 |
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