scid-beige

scid-beige Spontaneous Mutant Mouse Model
  • Live
  • Mouse
  • Male & Female Available
  • Albino
  • Available for direct purchase by CRO
Model No.NomenclatureGenotype
CBSCBG-F C.B-Igh-1b/GbmsTac-Prkdcscid-Lystbg N7sp/sp;sp/sp
CBSCBG-M C.B-Igh-1b/GbmsTac-Prkdcscid-Lystbg N7sp/sp;sp/sp
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Overview

Nomenclature: C.B-Igh-1b/GbmsTac-Prkdcscid-Lystbg N7

  • The mutations were backcrossed seven generations to the congenic C.B-17 background
  • This double mutant model carries the scid mutation which causes a lack of both T and B lymphocytes due to a defect in V(D)J recombination
  • It also carries the beige mutation which results in cytotoxic T cell and macrophage defects as well as selective impairment of NK cell functions. As a result, scid-beige mice are potentially an improved model for receipt of xenotransplants and for infectious disease studies
  • It has also been observed that the C.B-17 scid-beige strain has a lower incidence of serum Ig relative to the C.B.-17 scid strain
Orders by weight: Taconic cannot routinely accept orders by weight for this model due to colony size. Please inquire for options if weight is critical for your experiment.

Origin

The scid-beige Spontaneous mutant model was developed by Dr. Anne Croy et al of the University of Guelph in April 1993 by intercrossing C.B.-17 from R. A. Phillips to C57BL/6-bg from the Jackson Laboratory. The beige (Lyst bg) mutation was backcrossed seven generations (N7) to a C.B.-17 scid spontaneous mutant background from the Ontario Cancer Institute.

Genetics

Species:Mouse
Strain Type:Congenic
Allele Type:Spontaneous Mutant
Coat Color:Albino
Coat Color Loci: Tyrp1b, Tyrc, Lystbg
Genetic Background:BALB/c
Coat Color Loci: Tyrp1b, Tyrc, Lystbg

Other Genetic Notes:

Refer to the C.B-17 (background strain) for genetic data

Guides & Publications

Applications & Therapeutic Areas

  • Cell and Tissue Humanized
  • Immunology
  • Inflammation
  • Oncology & Immuno-Oncology

Transit, Housing & Welfare

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Packing Practices

Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns.  When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.

Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age."  Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.

Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.

Data

Average litter size: 6

Licensing

Terms of Sale and Use for scid-beige

These models are sold subject to Taconic's Terms and Conditions for Taconic's Models, Products and Services

Pricing - USD

Opportunist Free (OF) Health Standard

CBSCBG Female

CBSCBG-F Genotype sp/sp;sp/sp

Age in WeeksQuantity 1 - 999
3 to 6$99.00
7 to 10$111.00

CBSCBG Male

CBSCBG-M Genotype sp/sp;sp/sp

Age in WeeksQuantity 1 - 999
3 to 6$99.00
7 to 10$111.00
11 to 12$123.00

Defined Flora (DF) Health Standard

CBSCBG Female

CBSCBG-F Genotype sp/sp;sp/sp

Age in WeeksQuantity 1 - 999
3 to 6$197.00
7 to 10$222.00

CBSCBG Male

CBSCBG-M Genotype sp/sp;sp/sp

Age in WeeksQuantity 1 - 999
3 to 6$197.00
7 to 10$222.00

Pricing - EUR

Opportunist Free (OF) Health Standard

CBSCBG Female

CBSCBG-F Genotype sp/sp;sp/sp

Age in WeeksQuantity 1 - 999
3 to 6€103,00
7 to 10€114,00

CBSCBG Male

CBSCBG-M Genotype sp/sp;sp/sp

Age in WeeksQuantity 1 - 999
3 to 6€103,00
7 to 10€114,00
11 to 12€127,00

Defined Flora (DF) Health Standard

CBSCBG Female

CBSCBG-F Genotype sp/sp;sp/sp

Age in WeeksQuantity 1 - 999
3 to 6€206,00
7 to 10€227,00

CBSCBG Male

CBSCBG-M Genotype sp/sp;sp/sp

Age in WeeksQuantity 1 - 999
3 to 6€206,00
7 to 10€227,00

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