Flp Deleter

Flp Deleter Random Transgenic Mouse Model
  • Live
  • Mouse
  • Male & Female Available
  • Black
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
7089-FC57BL/6-Tg(CAG-Flpe)2Artetg/wt
7089-MC57BL/6-Tg(CAG-Flpe)2Artetg/wt
7089-FC57BL/6-Tg(CAG-Flpe)2Artetg/tg
7089-MC57BL/6-Tg(CAG-Flpe)2Artetg/tg
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Overview

Nomenclature: C57BL/6-Tg(CAG-Flpe)2Arte

  • Ubiquitously active general Flp deleter.
  • In vitro-derived Flp recombinase under the control of the chicken beta-actin promoter and an hCMV immediate early enhancer. The use of the chimeric CMV enhancer/beta-actin promoter leads to a ubiquitous expression profile in eukaryotes. The Flp recombinase carries a minimal, nuclear localization signal from the SV40 larger T-antigen. Additional elements of the expression cassette are an intron with splice donor and acceptor sites upstream of the Flp gene and a synthetic polyadenylation signal downstream of the Flp.
  • This colony is currently being intracrossed to homozygosity. In the interim, mice may be sold as carriers. Mice with a genotype of Carrier(C) carry the transgene, but may be either hemizygous or homozygous.
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Origin

The Flp Deleter mouse was developed by Artemis Pharmaceuticals (now Taconic). The mutation was introduced through random integration (microinjection) of the CAGGS-Flpe into C57BL/6 zygotes. The line was backcrossed 10 generations to C57BL/6NTac and intercrossed to homozygosity. The line was rederived in 2013 and is currently being intracrossed to homozygosity.

Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Recombinase-expressing;Random transgenic
Coat Color:Black
Genetic Background:C57BL/6

Applications & Therapeutic Areas

  • Model Generation Solutions
  • Recombinase-mediated Gene Deletion
  • Transgenic Model Generation Support

Transit, Housing & Welfare

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Packing Practices

Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns.  When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.

Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age."  Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.

Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.

Licensing

Access to this model requires execution of a Flp Deleter Crossbreeding Agreement. There are two types of agreements, a one-time license which permits a single crossbreeding event to a specific mouse line or a broad license which permits crossbreeding to an unlimited number of lines during the term.

The fees for a Flp Deleter Crossbreeding Agreement that permits crossing of the Flp Deleter to ONE (1) specified frted line is:
  • $650/€575 per line for non-profit users
  • $1,700/€1.530 per line for for-profit users
The fees for a Flp Deleter Crossbreeding Agreement that permits crossing of the Flp Deleter to an unlimited number of lines during the term is:
  • $4,725/€4.300 per year for non-profit users
  • $12,600/€11.470 per year for for-profit users
Once the agreement is executed, you may order mice for use in crossbreeding. Please contact Taconic Customer Service for details.

Pricing - USD

Opportunist Free (OF) Health Standard

7089 Female

7089-F Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 12$475.00

7089-F Genotype tg/wt

Age in WeeksQuantity 1 - 999
3 to 10$475.00

7089 Male

7089-M Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 12$475.00

7089-M Genotype tg/wt

Age in WeeksQuantity 1 - 999
3 to 10$475.00

Pricing - EUR

Opportunist Free (OF) Health Standard

7089 Female

7089-F Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 12€432,00

7089-F Genotype tg/wt

Age in WeeksQuantity 1 - 999
3 to 10€432,00

7089 Male

7089-M Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 12€432,00

7089-M Genotype tg/wt

Age in WeeksQuantity 1 - 999
3 to 10€432,00

Pricing - USD Nonprofit

Opportunist Free (OF) Health Standard

7089 Female

7089-F Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 12$475.00

7089-F Genotype tg/wt

Age in WeeksQuantity 1 - 999
3 to 10$475.00

7089 Male

7089-M Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 12$475.00

7089-M Genotype tg/wt

Age in WeeksQuantity 1 - 999
3 to 10$475.00

Pricing - EUR Nonprofit

Opportunist Free (OF) Health Standard

7089 Female

7089-F Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 12€432,00

7089-F Genotype tg/wt

Age in WeeksQuantity 1 - 999
3 to 10€432,00

7089 Male

7089-M Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 12€432,00

7089-M Genotype tg/wt

Age in WeeksQuantity 1 - 999
3 to 10€432,00

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2024 Pricing Guide Now Available

Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.