Model No. | Nomenclature | Genotype |
---|---|---|
17758-F | C57BL/6NTac-Igh-Jem1Tac | ko/ko |
17758-M | C57BL/6NTac-Igh-Jem1Tac | ko/ko |
Model No. | Nomenclature | Genotype |
---|---|---|
17758-F | C57BL/6NTac-Igh-Jem1Tac | ko/ko |
17758-M | C57BL/6NTac-Igh-Jem1Tac | ko/ko |
Nomenclature: C57BL/6NTac-Igh-Jem1Tac
Origin
Initial Publication: There is no specific publication describing the generation of these mice, but multiple publications exist demonstrating applications using a similar model on the BALB/c background (Taconic model #1147). See reference list.
Other Publications: Lan Y, Zhang D, Xu C, Hance KW, Marelli B, Qi J, Yu H, Qin G, Sircar A, Hernández VM, Jenkins MH, Fontana RE, Deshpande A, Locke G, Sabzevari H, Radvanyi L, Lo KM. Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β. Sci Transl Med. 2018 Jan 17;10(424):eaan5488.
Xu C, Zhang Y, Rolfe PA, Hernández VM, Guzman W, Kradjian G, Marelli B, Qin G, Qi J, Wang H, Yu H, Tighe R, Lo KM, English JM, Radvanyi L, Lan Y. Combination Therapy with NHS-muIL12 and Avelumab (anti-PD-L1) Enhances Antitumor Efficacy in Preclinical Cancer Models. Clin Cancer Res. 2017 Oct 1;23(19):5869-5880.
Smith KM, Rahman RS, Spencer LA. Humoral Immunity Provides Resident Intestinal Eosinophils Access to Luminal Antigen via Eosinophil-Expressed Low-Affinity Fcγ Receptors. J Immunol. 2016 Nov 1;197(9):3716-3724.
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Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Conditions of Use specific to Taconic Transgenic Models™ generated using CRISPR/Cas9
Age in Weeks | Quantity 1 - 999 |
3 to 10 | $218.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | $218.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | €198,00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | €198,00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | $218.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | $218.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | €198,00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | €198,00 |
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