Oatp1a/1b Cluster Knockout Mouse

Oatp1a/1b Cluster Constitutive Knockout Mouse Model
  • Live
  • Mouse
  • Male & Female Available
  • Albino
  • Available for direct purchase by CRO
  • Taconic Transgenic Model
Model No.NomenclatureGenotype
10707-FFVB.129P2-Del(Slco1b2-Slco1a5)1Ahsko/ko
10707-MFVB.129P2-Del(Slco1b2-Slco1a5)1Ahsko/ko
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Overview

Nomenclature: FVB.129P2-Del(Slco1b2-Slco1a5)1Ahs

  • This model carries a deletion of all five established Slco1a and 1b and two predicted Slco1a-like mouse genes.
  • Contains a cre-mediated deletion of the following established genes in the Slco1a/1b cluster: Slco1a1, Slco1a4, Slco1a5, Slco1a6 and Slco1b2.
  • OATPs facilitate sodium-independent uptake transport of a wide variety of organic endo and exogenous compounds, such as bile acids, steroid and thyroid hormones and their conjugates, and numerous drugs and toxins.
  • Useful in dissecting the contribution of the Slco1a/1b family in these processes.
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Origin

The Oatp1a/1b Cluster Knockout Mouse was developed in the laboratory of Alfred Schinkel of the Netherlands Cancer Institute in 2010. The model was generated by insertion of loxP sites into the Slco1a5 and Slco1b2 genes at both ends of the Slco1a/1b gene cluster in E14 embryonic stem cells derived from 129P2/OlaHsd mice, followed by Cre-mediated deletion and injecting the targeted cells into C57BL/6J blastocysts. Resultant chimeras were backcrossed to FVB/N mice for at least 7 generations (N7). Taconic received stock in 2010. The mice were derived by embryo transfer and are maintained by incrossing of homozygous mice.

Genetics

Species:Mouse
Strain Type:Congenic
Allele Type:Constitutive Knockout
Coat Color:Albino
Genetic Background:FVB

Other Genetic Notes:

Wild type for Nnt mutation; carries Pde6brd1 mutation

Guides & Publications

Initial Publication: van de Steeg E, Wagenaar E, van der Kruijssen CM, Burggraaff JE, de Waart DR, Elferink RP, Kenworthy KE, Schinkel AH (2010). Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. J. Clin. Invest. 120(8): 2942-52.

Applications & Therapeutic Areas

  • ADMET

Transit, Housing & Welfare

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10707 males are packed as cagemates, without recombination of animals from different cages into a single Taconic Transit Cage (TTC). We recommend that customers do NOT recombine 10707 males from different Taconic Transit Cages into the same cage at or after unpacking. 

Packing Practices

Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns.  When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.

Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age."  Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.

Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.

Contract Services

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Oatp1a/1b Cluster Knockout Mouse

Conditions of Use for Taconic Transgenic Models™

Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:

  • Title to these Models and biological materials derived from them remains with Taconic.
  • The Models will be used for research purposes only.
  • The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
  • Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.

Pricing - USD

Murine Pathogen Free (MPF) Health Standard

10707 Female

10707-F Genotype ko/ko

Age in WeeksQuantity 1 - 999
3 to 10$425.00

10707 Male

10707-M Genotype ko/ko

Age in WeeksQuantity 1 - 999
3 to 10$425.00

Pricing - EUR

Murine Pathogen Free (MPF) Health Standard

10707 Female

10707-F Genotype ko/ko

Age in WeeksQuantity 1 - 999
3 to 10€387,00

10707 Male

10707-M Genotype ko/ko

Age in WeeksQuantity 1 - 999
3 to 10€387,00

Pricing - USD Nonprofit

Murine Pathogen Free (MPF) Health Standard

10707 Female

10707-F Genotype ko/ko

Age in WeeksQuantity 1 - 999
3 to 10$425.00

10707 Male

10707-M Genotype ko/ko

Age in WeeksQuantity 1 - 999
3 to 10$425.00

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