| Model No. | Nomenclature | Genotype |
|---|---|---|
| 10707-F | FVB.129P2-Del(Slco1b2-Slco1a5)1Ahs | ko/ko |
| 10707-M | FVB.129P2-Del(Slco1b2-Slco1a5)1Ahs | ko/ko |
Oatp1a/1b Cluster Knockout Mouse
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Overview
Nomenclature: FVB.129P2-Del(Slco1b2-Slco1a5)1Ahs
- This model carries a deletion of all five established Slco1a and 1b and two predicted Slco1a-like mouse genes.
- Contains a cre-mediated deletion of the following established genes in the Slco1a/1b cluster: Slco1a1, Slco1a4, Slco1a5, Slco1a6 and Slco1b2.
- OATPs facilitate sodium-independent uptake transport of a wide variety of organic endo and exogenous compounds, such as bile acids, steroid and thyroid hormones and their conjugates, and numerous drugs and toxins.
- Useful in dissecting the contribution of the Slco1a/1b family in these processes.
Origin
Genetics
Guides & Publications
Initial Publication: van de Steeg E, Wagenaar E, van der Kruijssen CM, Burggraaff JE, de Waart DR, Elferink RP, Kenworthy KE, Schinkel AH (2010). Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. J. Clin. Invest. 120(8): 2942-52.
Applications & Therapeutic Areas
- ADMET
Transit, Housing & Welfare
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10707 males are packed as cagemates, without recombination of animals from different cages into a single Taconic Transit Cage (TTC). We recommend that customers do NOT recombine 10707 males from different Taconic Transit Cages into the same cage at or after unpacking.
Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
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Oatp1a/1b Cluster Knockout Mouse
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
- Title to these Models and biological materials derived from them remains with Taconic.
- The Models will be used for research purposes only.
- The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
- The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
- Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Pricing - USD
Murine Pathogen Free (MPF) Health Standard
10707 Female
10707-F Genotype ko/ko
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | $429.00 |
10707 Male
10707-M Genotype ko/ko
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | $429.00 |
Pricing - EUR
Murine Pathogen Free (MPF) Health Standard
10707 Female
10707-F Genotype ko/ko
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | €365,00 |
10707 Male
10707-M Genotype ko/ko
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | €365,00 |
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