| Model No. | Nomenclature | Genotype |
|---|---|---|
| B6NU | B6.Cg/NTac-Foxn1nu NE10 | sp/sp |
| B6NU-M | B6.Cg/NTac-Foxn1nu NE10 | sp/sp |
| B6NU-F | B6.Cg/NTac-Foxn1nu NE10 | sp/wt |
B6 nude
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Overview
Nomenclature: B6.Cg/NTac-Foxn1nu NE10
- Foxn1nu mutation backcrossed to the C57BL/6NTac inbred strain for ten generations
- Tissues from the C57BL/6 Nude can be transplanted onto normal C57BL/6 mice
- The autosomal recessive nude gene in homozygous (sp/sp) mice causes the lack of fur and an abnormal thymus. The deficiency in T cell function allows athymic mice to accept and grow xenografts as well as allografts of normal and malignant tissues.
- Heterozygous (sp/wt) mice carry only one copy of the nude mutation and have hair. Heterozygous nudes were originally thought to have normal immune systems, but in fact have immune alterations such as reduced bone marrow stem cells and lower thymus weights. Heterozygous nudes may thus not be appropriate for use as sentinels. They may be used in PK/dosing studies.
Origin
The NIH Animal Genetic Resource received the B6 Nude Spontaneous mutant model in 1980. The mice were backcrossed nine generations (N9). In 2007 an additional backcross was completed to bring to N10.
Genetics
Guides & Publications
Applications & Therapeutic Areas
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- Oncology & Immuno-Oncology
- Inflammation
Transit, Housing & Welfare
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Diet
Data
Average litter size: 8
Taconic cannot routinely accept orders by weight for this model due to colony size. Please inquire for options if weight is critical for your experiment.
n= 100 per sex at RF health standards from US colonies. Data collected 2011-12.
High and Low represent mean +/- 1 standard deviation.
Based on sample size the charts above represents ~70% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves. Growth charts are provided only as a guide, if a specific weight criteria is needed please order animals by weight.
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