| Model No. | Nomenclature | Genotype |
|---|---|---|
| 10679 | NTac:SD-Tg(SNCA*E46K)70CJLi | Inquire for genotype |
Human Alpha Synuclein E46K Rat
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Overview
Nomenclature: NTac:SD-Tg(SNCA*E46K)70CJLi
- Line 10679 Rat carries the E46K mutation on the human gene SNCA. Hemizygotes are positive for the E46K mutation.
- The E46K alpha-synuclein mutation is linked to the development of Parkinson's disease, especially familial Parkinson's Disease
- Atrophy of the substantia nigra and build-up of Lewy bodies is associated with the E46K alpha-synuclein mutation.
Origin
Line 10679 was developed in the laboratory of Chenjian Li at Cornell. The model was created through pronuclear injection of human gene SNCA with the E46K mutation into NTac:SD zygotes. Founder line 70 was bred to NTac:SD. The colony is maintained by mating a wild type female with a hemizygous male to produce hemizygous pups. Taconic received stock from Cornell in 2010 and derived the rats through embryo transfer derivation.
Source: Model Sponsor: The Michael J. Fox Foundation
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication:
Cannon, J.R., et al., Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to 3 mitochondrial impairment. Exp Neurol. 2012 Nov 12;240C:44-56. doi: 10.1016/j.expneurol.2012.11.007. [Epub ahead of print]
Applications & Therapeutic Areas
- Neuroscience
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Licensing
Terms of Use:
Rats may be cryo-recovered at Taconic. Nonprofit users may access rats for research purposes under a simple label license (no signatures required). For-profit users must first execute a license agreement with Cornell University.
Conditions of Use for Parkinson's Disease Rat Models for Nonprofit Users:
The Parkinson's Disease Rat Models (Model), Taconic Models 10678, 10679, 10680, and 10681, are produced and distributed under rights to patents and/or intellectual property owned by Cornell University (Cornell). Taconic has rights to distribute the Model on behalf of Cornell. Cornell maintains ownership of the Model and permits the sale of such rats to each Buyer that agrees to the following Terms and Conditions of the Sale and following terms of use:
- Title to the Model and biological materials derived from it remains with Cornell.
- The Model will be used for research purposes only.
- The Model may be bred, but may not be crossbred to another transgenic line or backcrossed to another strain background without the written consent of Cornell.
- In publications of results with the Model, Recipient must cite Chenjian Li of Weill Cornell Medical College as creator of the Model.
- The Model and biological materials derived from it will not be distributed to third parties (except to send tissues to a nonprofit collaborator or for fee-for-service staining or analysis work).
- The Model and biological materials derived from it will not be used for commercial purposes.
- Recipient may not use Model in research funded by a for-profit entity unless said for-profit has obtained a license for the Model from Cornell.
- Recipient assumes all risk from using the Model and holds Cornell and its employees harmless.
For licensing information, contact:
Cornell Center for Technology Enterprise and Commercialization
Attention: Executive Director
395 Pine Tree Road, Suite 310
Ithaca, NY 14850
Fax: 607-254-5454
Phone: 607-254-5236
Email: cctec-contracts@cornell.edu
Cite: Docket D4184 (LRRK2) and D5203 (alpha-synuclein)
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