Taconic Biosciences offers a number of Live and Cryopreserved models for Parkinson's Disease (PD) research. Click each card to learn more about the model.
The Michael J. Fox Foundation Parkinson’s Disease Catalog—Mice and Rats for PD Research
Learn more about Taconic Biosciences' partnership with The Michael J. Fox Foundation
"The Michael J. Fox Foundation (MJFF) is dedicated to finding a cure for Parkinson's disease (PD) through an aggressively funded research agenda and to ensuring the development of improved therapies for those living with Parkinson's today. The MJFF Research Tools Program supports this mission through the development, characterization, and distribution of high-quality reagents and models for PD research. Taconic Biosciences has partnered with MJFF in this program since 2010, generating and sharing critical rodent models for PD research. These models and other reagents generated by the MJFF Research Tools Program can be found at michaeljfox.org/research-tools."
- Nicole Polinski, Director of Research Resources
The Michael J. Fox Foundation for Parkinson’s Research
Parkinson's Disease Models—Mice and Rats for PD Research
LRRK2 G2019S Mouse
Summary
- • Species: Mouse
- • Strain Type: Inbred
- • Allele Type: Point Mutation
- • Genetic Background: C57BL/6
Applications & Therapeutic Areas
- • Neuroscience
- • Parkinson's Disease
Floxed Prkn Mouse
Summary
- • Species: Mouse
- • Strain Type: Outbred or Mixed
- • Allele Type: Conditional Knockout
- • Coat Color: Black
- • Genetic Background: Mixed: Line was developed on a C57BL/6J background. Line is currently on a mixed genetic background (83.48-84.24% of the genetic background is C57BL/6)/6
Applications & Therapeutic Areas
- • Neuroscience
- • Parkinson's Disease
Rab29 Overexpression Mouse
Summary
- • Species: Mouse
- • Strain Type: Inbred
- • Allele Type: Targeted Transgenic
- • Coat Color: Black
- • Genetic Background: C57BL
Applications & Therapeutic Areas
- • Parkinson's Disease
Human Alpha Synuclein A53T Rat
Summary
- • Species: Rat
- • Strain Type: Outbred or Mixed
- • Allele Type: Random Transgenic;Genetically Humanized
- • Coat Color: Albino
- • Genetic Background: SD
Applications & Therapeutic Areas
- • Neuroscience
- • Parkinson's Disease
Human Alpha Synuclein E46K Rat
Summary
- • Species: Rat
- • Strain Type: Outbred or Mixed
- • Allele Type: Random Transgenic; Genetically Humanized
- • Coat Color: Albino
- • SD
Applications & Therapeutic Areas
- • Neuroscience
- • Parkinson's Disease
Human Alpha Synuclein Rat
Summary
- • Species: Rat
- • Strain Type: Outbred or Mixed
- • Allele Type: Random Transgenic; Genetically Humanized
- • Coat Color: Albino
- • Genetic Background: SD
Applications & Therapeutic Areas
- • Neuroscience
- • Parkinson's Disease
Human LRRK2 G2019S Rat
Summary
- • Species: Rat
- • Strain Type: Outbred or Mixed
- • Allele Type: Random Transgenic;Genetically Humanized;Point Mutation
- • Coat Color: Albino
- • Genetic Background: SD
Applications & Therapeutic Areas
- • Neuroscience
- • Parkinson's Disease
hTH-GFP Rat (X-linked)
Summary
- • Species: Rat
- • Strain Type: Outbred or Mixed
- • Allele Type: Reporter; Random Transgenic
- • Coat Color: Albino
- • Genetic Background: SD
Applications & Therapeutic Areas
- • Neuroscience
- • Parkinson's Disease
- • Reporter Lines
hTH-GFP Rat (Autosomal Insertion)
Summary
- • Species: Rat
- • Strain Type: Outbred or Mixed
- • Allele Type: Reporter; Random Transgenic
- • Coat Color: Albino
- • Genetic Background: SD
Applications & Therapeutic Areas
- • Neuroscience
- • Parkinson's Disease
- • Reporter Lines
Coming Soon: New Rodent Models for Parkinson's Disease Research
22966 | April 2025
aSyn SNCA KO Rat
22966 | April 2025
aSyn A53T SNCA KI Rat
22640 | June 2025
PINK1 KO Rat
22574 | June 2025
Rab32 S69R KI Mouse
22952 | July 2025
Prkn KO
Rat
December 2025
LRRK2 KO
Rat
23196 | Spring 2026
Prkn/PINK1 dKO Rat
Why Mice and Rats are Essential for Parkinson’s Disease Research and Drug Discovery
Mouse models play a crucial role in Parkinson's disease (PD) research by replicating human disease mechanisms, enabling the study of genetic contributions, testing new treatments, and advancing personalized medicine. These models, including genetically modified mice, mimic the degeneration of dopamine-producing neurons, allowing researchers to explore the progression of PD and identify potential intervention points. They are invaluable in testing new therapies, screening drugs, and investigating disease pathways, such as the accumulation of alpha-synuclein and Lewy body formation. Additionally, mouse models help researchers better understand genetic factors by creating transgenic mice that carry specific PD-related mutations, and they are essential in developing more tailored treatment approaches. Ultimately, these models are key to discovering effective treatments and working toward a cure for Parkinson’s disease.
About The Michael J. Fox Foundation
The Michael J. Fox Foundation (MJFF) exists for one reason: to accelerate the next generation of Parkinson’s disease (PD) treatments. In practice, that means identifying and funding projects most vital to patients; spearheading solutions around seemingly intractable field-wide challenges; coordinating and streamlining the efforts of multiple, often disparate, teams; and doing whatever it takes to drive faster knowledge turns for the benefit of every life touched by PD.
Related Parkinson's Disease (PD) Resources
