Changes in gene names, along with a reversal of allele designation in 1987, have led to much confusion regarding antigen specificity of the Ptprc gene. Ptprc is the gene symbol for the protein tyrosine phosphatase, receptor type C. Komura, et al. (1975), first described a T cell antigen and classified it as Ly5.1 in C57BL/6 mice and Ly5.2 in SJL mice. To follow gene nomenclature, these designations became Ly5a for the B6 and Ly5b for the SJL.
In 1987, Morse et al proposed a change in murine lymphocyte antigen names, which led to a reversal of the previous designation. Thus, beginning in 1987, the B6 genotype became Ly5b (Ly5.2 antigen specificity) and the SJL became Ly5a (Ly5.1).
An additional change was made in 1992, when the gene name changed to Cd45, leading to SJL designation as Cd45a (Cd45.1) and B6 designation as Cd45b (Cd45.2).
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