| Model No. | Nomenclature | Genotype |
|---|---|---|
| 9662-F | CB6F1-Tg(HLA-A*0101/H2-Kb)A1.01 | tg/wt |
| 9662-M | CB6F1-Tg(HLA-A*0101/H2-Kb)A1.01 | tg/wt |
| 9662-F | CB6F1-Tg(HLA-A*0101/H2-Kb)A1.01 | wt/wt |
| 9662-M | CB6F1-Tg(HLA-A*0101/H2-Kb)A1.01 | wt/wt |
HLA-A1 (CB6F1)
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Overview
Nomenclature: CB6F1-Tg(HLA-A*0101/H2-Kb)A1.01
- Carries a transgene consisting of fragments of the human HLA-A*0101 gene and mouse H2-Kb gene which encodes a chimeric class I molecule consisting of the human HLA-A1 leader, α1 and α2 domains ligated to the murine α3, transmembrane and cytoplasmic H2-Kb domains
- Expresses the chimeric HLA-A1 class I molecule on the surface of T and B cells
- Represents the human HLA-A1 supertype
- Useful for infectious disease research, vaccine development and testing, safety and immunogenicity testing as well as research directed towards oncology and autoimmune disorders
- Permits identification of epitopes restricted to the HLA-A1 supertype
- Taconic offers this allele on two different backgrounds, CB6F1 and C57BL/6. Model #9659 is on a CB6F1 background and is recommended for most applications, including vaccine research and general epitope identification. The HLA-A1 (C57BL/6), model #8909, is recommended specifically for syngeneic tumor studies utilizing C57BL/6-derived tumors and for crossbreeding to other GEM lines on the C57BL/6 background (inquire regarding crossbreeding rights).
Origin
Genetics
Guides & Publications
Initial Publication: Depla E, Van der Aa A, Livingston BD, Crimi C, Allosery K, De Brabandere V, Krakover J, Murthy S, Huang M, Power S, Babé L, Dahlberg C, McKinney D, Sette A, Southwood S, Philip R, Newman MJ, Meheus L. (2008) Rational design of a multiepitope vaccine encoding T-lymphocyte epitopes for treatment of chronic hepatitis B virus infections. J Virol. 82(1):435-50.
Applications & Therapeutic Areas
- Immunology
- Infectious Disease
- Safety Assessment
- Vaccine Research
- Inflammation
Transit, Housing & Welfare
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Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
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HLA-A1 (CB6F1)
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
- Title to these Models and biological materials derived from them remains with Taconic.
- The Models will be used for research purposes only.
- The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
- The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
- Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Pricing - USD
Murine Pathogen Free (MPF) Health Standard
9662 Female
9662-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $425.00 |
9662 Male
9662-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $425.00 |
Pricing - EUR
Murine Pathogen Free (MPF) Health Standard
9662 Female
9662-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €387,00 |
9662 Male
9662-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €387,00 |
Pricing - USD Nonprofit
Murine Pathogen Free (MPF) Health Standard
9662 Female
9662-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $250.00 |
9662 Male
9662-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $250.00 |
Pricing - EUR Nonprofit
Murine Pathogen Free (MPF) Health Standard
9662 Female
9662-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €228,00 |
9662 Male
9662-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €228,00 |
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