Nomenclature: CB6F1-Tg(HLA-B*4002/H2-Kb)B44.01

• Carries a transgene consisting of fragments of the human HLA-B*4002 gene and mouse H2-K^b gene which encodes a chimeric class I molecule consisting of the human HLA-B44 leader, α1 and α2 domains ligated to the murine α3, transmembrane and cytoplasmic H2-K^b domains
• Expresses the chimeric HLA-B44 class I molecule on the surface of T and B cells.
• Represents the human HLA-B44 supertype. The B*40:02 allele is a member of the B44-binding supertype, which encompasses a group of HLA B alleles sharing a binding specificity for peptides with E in position 2 and aliphatic/hydrophobic residues at the C-terminus. B61 is a serological designation. The B61 serological antigen is present on several B*40 subtypes (including B*40:02). With one possible exception, all alleles with the B61 serological antigen are expected to share the same main binding specificity as B*40:02, and hence have been defined as members of the B44 binding supertype.
• Useful for infectious disease research, vaccine development and testing, safety and immunogenicity testing as well as research directed towards oncology and autoimmune disorders
• Permits identification of epitopes restricted to the HLA-B44 supertype
• Taconic offers this allele on two different backgrounds, CB6F1 and C57BL/6. Model #9659 is on a CB6F1 background and is recommended for most applications, including vaccine research and general epitope identification. The HLA-B44 (C57BL/6), model 8911, is recommended specifically for syngeneic tumor studies utilizing C57BL/6-derived tumors and for crossbreeding to other GEM lines on the C57BL/6 background (inquire regarding crossbreeding rights).

Origin