| Model No. | Nomenclature | Genotype |
|---|---|---|
| 2508-F | STOCKTg(Prnp-MAPT*P301L)JNPL3Hlmc | tg/tg |
| 2508-M | STOCKTg(Prnp-MAPT*P301L)JNPL3Hlmc | tg/tg |
Tau - Model 2508
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Overview
Nomenclature: STOCKTg(Prnp-MAPT*P301L)JNPL3Hlmc
- Carries the transgene for the human P301L mutation of the microtubule-associated protein tau gene (MAPT) and expresses mutant human TAU protein
- Aggregates of filaments of TAU result in Neurofibrillary tangles (NFT) which are associated with Alzheimer's disease, Pick disease and other neurological syndromes
- Develops behavioral and motor disturbances related to development of NFT
- Model 2508 is homozygous for the transgene and develops a phenotype that mimics human tauopathies in a more rapid time frame than hemizygous mice
- Useful for studying Alzheimer's disease, Pick's disease and other neurological syndromes associated with NFT
- This model is on a C57BL/6, DBA/2, SW mixed background.
- The appropriate wild type control stock is model #18392.
- Pink eyed animals, associated with certain coat colors, and the Pde6brd1 retinal degeneration mutation can cause light sensitivity and/or blindness in some animals. This may impact the results of behavioral testing. Upon request, animals can be screened for eye color, coat color, and/or rd1 homozygosity for an additional fee.
Origin
Genetics
Guides & Publications
Initial Publication: Lewis J, McGowan E, Rockwood J, Melrose H, Nacaraju P, Van Slegtenhorst M, Gwinn-Hardy K, Murphy MP, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin W-L, Yen S-H, Dickson DW, Davies P, Hutton M. (2000) Neurofibrillary Tangles, Amyotrophy and Progressive Motor Disturbance in Mice Expressing Mutant (P301L) Tau Protein. Nat Genet, 25(4):402-406.
Applications & Therapeutic Areas
- "Alzheimers Disease"
- Genetically Humanized
- Neuroscience
Transit, Housing & Welfare
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2508 males are packed as cagemates without recombination of animals from different cages into a single Taconic Transit Cage (TTC). We recommed that the customers do NOT recombine 2508 males from different Taconic Transit Cages into the same cage at or after unpacking.
Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
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Tau - Model 2508
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
- Title to these Models and biological materials derived from them remains with Taconic.
- The Models will be used for research purposes only.
- The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
- The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
- Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Pricing - USD
Murine Pathogen Free (MPF) Health Standard
2508 Female
2508-F Genotype tg/tg
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | $550.00 |
2508 Male
2508-M Genotype tg/tg
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | $550.00 |
Pricing - EUR
Murine Pathogen Free (MPF) Health Standard
2508 Female
2508-F Genotype tg/tg
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | €501,00 |
2508 Male
2508-M Genotype tg/tg
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | €501,00 |
Pricing - USD Nonprofit
Murine Pathogen Free (MPF) Health Standard
2508 Female
2508-F Genotype tg/tg
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | $425.00 |
2508 Male
2508-M Genotype tg/tg
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | $425.00 |
Pricing - EUR Nonprofit
Murine Pathogen Free (MPF) Health Standard
2508 Female
2508-F Genotype tg/tg
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | €387,00 |
2508 Male
2508-M Genotype tg/tg
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | €387,00 |
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