Humanized immune system (HIS) mice are the most robust and translatable rodent models available for immuno-oncology research. We design these models to recapitulate important aspects of the human immune system, empowering you to more accurately evaluate novel therapeutics. Taconic offers multiple genetically engineered models for custom, in-house humanization as well as HSC- and PBMC-engrafted study-ready models. Explore our portfolio ranging from immunodeficient models based on the CIEA NOG mouse® to the exclusive FcResolv™ huNOG mouse model.
Humanized Immune System Mice
HIS Mice for Preclinical Studies
As drug discovery efforts rapidly shift towards increasingly complex and highly specific biologic therapeutics, sourcing appropriate in vivo models for preclinical work is becoming more challenging. Researchers are turning to our HIS models for help addressing their in vivo drug research challenges.
HIS models are created by engrafting CD34+ hematopoietic stem cells (HSCs), peripheral blood mononuclear cells (PBMCs), or other human immune cells into an immunodeficient mouse. Taconic offers expert engraftment and a broad selection of NOG models to suit multiple application areas and project types.
- Available HIS Models
- Additional HIS Host Strains
- The NOG Portfolio
- HIS Model Resources
Available HIS Models
Easiest Access to Humanized Immune System Mice
- Start projects sooner with off-the-shelf inventory available within days, not months.
- Taconic humanized immune system (HIS) mice are distributed with no additional licensing requirements under clear for-profit terms of use and nonprofit terms of use.
- Taconic Biosciences is the only rodent model provider empowering customers to obtain models without an MTA or commercial use license.
Which huNOG-EXL model is right for you?
- The Taconic portfolio of HIS mice includes the huNOG-EXL SA (Standard Access) model and the huNOG-EXL EA (Early Access) model. Each model supports different types of studies. Visit the huNOG-EXL Model page to determine which best suits your application.
Additional HIS Host Strains
Making your own HIS mice? View additional host strains for humanization from the NOG Portfolio. Contact us for a free scientific consulation on determining the best base strain for your HIS model needs.
The NOG Portfolio of super immunodeficient and humanized immune system mouse models
Taconic's NOG mice are severely immunodeficient mouse models which accept the engraftment of heterologous cells more readily than traditional immunodeficient models, making them exceptional hosts for the production of mice with human immune systems. Selection of the right HIS model starts with consideration of the human cell type(s) of interest. The diagram below indicates the predominant immune cells present in each model.
HIS Model Resources
Visit our Resources page to find Webinars, Insights, and White Papers to learn more and help navigate the possibilities for HIS mouse model utility and applications.
Experts to Drive Success
The correct application of research tools can be just as vital as the tools themselves in driving success. Taconic's PhD Field Application Scientists are a critical resource in delivering the best humanized model solution. Use the form below to request a consultation.
Taconic Field Application Scientists can support customers with:
- HIS mouse model selection and technical consultations
- Experimental study design
- Establishing collaborations that de-risk development of HIS mouse applications
- Identification of contract service providers with relevant model expertise and experience
What our customers say:
“Experimental Pharmacology &Oncology (EPO) GmbH uses 1st generation NOG mice provided by Taconic for its preclinical oncology service. These mice are included in novel concepts for the development of personalized treatment options and especially suited for humanization strategies. We are very satisfied with the quality of mice, the reliability of shipment and the high level of scientific support. Further, we very much appreciate the competent and always friendly communication.”
Experimental Pharmacology & Oncology (EPO) GmbH
- Section 2
What our customers say:
“Working with Taconic has been a great pleasure for Pharmatest. We are impressed with the high quality services, top-level scientific support, and fast and clear communication. By using humanized mice provided by Taconic, we have been able to establish more predictive animal models to support immuno-oncology therapy development.”
Dr. Jenni Bernoulli, COO at Pharmatest
Get In Touch
Book a complimentary consultation or get support for an existing order
If you need immediate assistance, please contact Customer Service:
Taconic Corporate Offices
Email: info@taconic.com
Phone: +1 (518) 697-3900
273 Hover Ave., Germantown, NY 12526
North American Customer Service
Email: info@taconic.com
Phone: +1 (518) 697-3915
Toll-free: +1 (888) 822-6642
Hours: (Monday - Friday): 7 a.m. - 6 p.m. ET
European Customer Service
Email: info@taconic.com
Phone (Europe and Denmark): +45 70 23 04 05
Phone (Germany): +49 214 50 68 023
Hours: (Monday - Friday): 7 a.m. - 5 p.m. CET
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