Abb/B2m

Abb/B2m Constitutive Knockout Mouse Model
  • Cryopreserved
  • Mouse
  • Black
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
4080 B6.129-H2-Ab1tm1Gru B2mtm1Jae N17Inquire for genotype
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Overview

Nomenclature: B6.129-H2-Ab1tm1Gru B2mtm1Jae N17

  • Contains a disruption of the H2-Ab1 gene
  • Expresses no A or E MHC class II molecules and therefore lacks most CD4+ T cells
  • Useful in transplantation, gene therapy and immunological disease research

Origin

The Abb/B2m multiple targeted mutation model was generated through the mating of B2m and Abb lines from the Jaenisch laboratory at the Whitehead Institute and the Glimcher lab at Harvard University, respectively. Abb mice at three backcrosses (N3) onto C57BL/6 were mated to B2m at eight backcrosses (N8) onto C57BL/6 in 1992 by Laurie Glimcher. The mice were then backcrossed to N17. Taconic received stock through the NIAID repository and embryo transfer derived the line in 1996. The line was maintained through mating of double homozygotes.

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse
Strain Type:Congenic
Allele Type:Constitutive Knockout
Coat Color:Black
Genetic Background:C57BL/6

Other Genetic Notes:

Wild type for Nnt mutation

Guides & Publications

Initial Publication: Grusby MJ, Auchincloss H Jr, Lee R, Johnson RS, Spencer JP, Zijlstra M, Jaenisch R, Papaioannou VE, Glimcher LH. (1993) Mice lacking major histocompatibility complex class I and class II moleculesProc Natl Acad Sci USA, 90(9):3913-3917.

Applications & Therapeutic Areas

  • Immunology
  • Inflammation

Transit, Housing & Welfare

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Abb/B2m

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.

Pricing - USD

4080

ItemCommercialNonprofit
Cryopreserved Model$29,400.00$21,000.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - EUR

4080

ItemCommercialNonprofit
Cryopreserved Model€22.050,00€17.850,00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

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Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.