| Model No. | Nomenclature | Genotype |
|---|---|---|
| 1004-F | B6.SJL-Tg(APOB)1102Sgy N20+? | tg/wt |
| 1004-M | B6.SJL-Tg(APOB)1102Sgy N20+? | tg/wt |
ApoB100
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Overview
Nomenclature: B6.SJL-Tg(APOB)1102Sgy N20+?
- Expresses high levels of human apolipoprotein B100
- ApoB100 mice show elevated serum levels of LDL cholesterol
- When fed a high fat diet, will develop significant foam cell accumulation underlying the endothelium and within the media, and develop significantly more complex atherosclerotic lesions than control animals
- Useful for identifying and evaluating compounds to reduce elevated levels of LDL cholesterol and the risk of atherosclerosis
- Also useful for studies of lipid transport and atherosclerosis
Origin
Genetics
Guides & Publications
Initial Publication: Linton MF, Farese RV, Chiesa G, Grass DS, Chin P, Hammer RE, Hobbs HH, Young SG. (1993). Transgenic Mice Expressing High Plasma Concentrations of Human Apolipoproteins B100 and Lipoprotein (a). J Clin Invest, 92: 3029-3037.
Applications & Therapeutic Areas
- Cardiovascular Disease
- Genetically Humanized
- Metabolic Disease
- Microbiome
Transit, Housing & Welfare
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Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
- Licensing
- Pricing - USD
- Pricing - EUR
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ApoB100
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
- Title to these Models and biological materials derived from them remains with Taconic.
- The Models will be used for research purposes only.
- The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
- The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
- Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Pricing - USD
Murine Pathogen Free (MPF) Health Standard
1004 Female
1004-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | $604.00 |
1004 Male
1004-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | $604.00 |
Pricing - EUR
Murine Pathogen Free (MPF) Health Standard
1004 Female
1004-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | €522,00 |
1004 Male
1004-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 3 to 10 | €522,00 |
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