Model No. | Nomenclature | Genotype |
---|---|---|
15660-F | BALB/cAnNTac-Il10em7Tac | ko/ko |
15660-M | BALB/cAnNTac-Il10em7Tac | ko/ko |
Model No. | Nomenclature | Genotype |
---|---|---|
15660-F | BALB/cAnNTac-Il10em7Tac | ko/ko |
15660-M | BALB/cAnNTac-Il10em7Tac | ko/ko |
Nomenclature: BALB/cAnNTac-Il10em7Tac
Origin
Initial Publication: There is no specific publication describing the generation of these mice. The initial publication describing application of these mice is as follows:
Covington, M., et al. Preclinical Characterization of Itacitinib (INCB039110), a Novel Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases. European Journal of Pharmacology 2020, 885:173505.
Additionally, multiple publications exist demonstrating applications using similar models. See reference list.
Other Publications:
Kühn R, Löhler J, Rennick D, Rajewsky K, Müller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 1993 Oct 22;75(2):263-74.
Berg DJ, Davidson N, Kühn R, Müller W, Menon S, Holland G, Thompson-Snipes L, Leach MW, Rennick D. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest. 1996 Aug 15;98(4):1010-20.
Sellon RK, Tonkonogy S, Schultz M, Dieleman LA, Grenther W, Balish E, Rennick DM, Sartor RB. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun. 1998 Nov;66(11):5224-31.
Kim SC, Tonkonogy SL, Karrasch T, Jobin C, Sartor RB. Dual-association of gnotobiotic IL-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis. Inflamm Bowel Dis. 2007 Dec;13(12):1457-66.
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All 15660 mice are packed as cagemates, without recombination of animals from different cages into a single Taconic Transit Cage (TTC). We recommend that customers do NOT recombine 15660 mice from different Taconic Transit Cages into the same cage at or after unpacking.
Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Conditions of Use specific to Taconic Transgenic Models™ generated using CRISPR/Cas9
Age in Weeks | Quantity 1 - 999 |
3 to 10 | $425.00 |
15660-RF Genotype ko/ko | Quantity 1 - 199 |
Retired Female Breeder | $503.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | $425.00 |
15660-RM Genotype ko/ko | Quantity 1 - 199 |
Retired Male Breeder | $503.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | €397,00 |
15660-RF Genotype ko/ko | Quantity 1 - 199 |
Retired Female Breeder | €468,00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | €397,00 |
15660-RM Genotype ko/ko | Quantity 1 - 199 |
Retired Male Breeder | €468,00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | $297.00 |
15660-RF Genotype ko/ko | Quantity 1 - 199 |
Retired Female Breeder | $352.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | $297.00 |
15660-RM Genotype ko/ko | Quantity 1 - 199 |
Retired Male Breeder | $352.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | €277,00 |
15660-RF Genotype ko/ko | Quantity 1 - 199 |
Retired Female Breeder | €328,00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | €277,00 |
15660-RM Genotype ko/ko | Quantity 1 - 199 |
Retired Male Breeder | €328,00 |
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